Every week, members of the Wilson Sayres' lab scour the most recent issues of dozens of journals for interesting and relevant (to lab research) articles. Here's what we found the week of October 16, 2015 (in no particular order within categories):
Conservation of regional variation in sex-specific chromosome regulation Wright et al. (2015) in Genetics
Predicting Carriers of Ongoing Selective Sweeps without Knowledge of the Favored Allele Ronen et al. (2015) in PLoS Genetics " The main contribution of this paper is the development and analysis of a new statistic (the HAF score), assigned to individual haplotypes. Using both theoretical analyses and simulations, we describe how the HAF scores differ for carriers and non-carriers of the favored allele, and how they change dynamically during a selective sweep."
A coalescent model for a sweep of a unique standing variant Berg and Coop (2015) in Genetics
Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots Baker et al. (2015) in PloS Genetics
Recurrent Domestication by Lepidoptera of Genes from Their Parasites Mediated by Bracoviruses Gasmi et al. (2015) in PLos Genetics "We show here that in several lineages, lepidopteran genomes have acquired genes from a bracovirus that is symbiotically used by parasitic wasps to inhibit caterpillar host immune defences. Integration of parts of the viral genome into host caterpillar DNA strongly suggests that integration can sporadically occur in the germline, leading to the production of lepidopteran lineages that harbor bracovirus sequences."
The spontaneous mutation rate in the fission yeast Schizosaccharomyces pombe Farlow et al. (2015) in Genetics
The genomics of organismal diversification illuminated by adaptive radiations Berner and Salzburger (2015) in Trends in Genetics
Genomic insights into a contagious cancer in Tasmanian devils Grueber et al. (2015) in Trends in Genetics
Human structural variation: mechanisms of chromosome rearrangements Weckselblatt and Rudd (2015) in Trends in Genetics
This Month in Genetics Garber (2015) in American Journal of Human Genetics
Genome-wide study of Down Syndrome-associated atrioventricular septal defects Ramachandran et al. (2015) in G3
Evidence of long-term gene flow and selection during domestication from analyses of Eurasian wild and domestic pig genomes. Frantz et al. (2015) in Nature Genetics
Multilane family evolution: perspectives from insect chemoreceptors. Benton (2015) in Trends in Ecology and Evolution
An Evolutionary Approach for Identifying Driver Mutations in Colorectal Cancer Foo et al. (2015) in PLOS Computational Biology "We design a novel statistical index, called the Hitchhiking Index, which reflects the probability that any observed candidate gene is a passenger alteration, given the frequency of alterations in a cross-sectional cancer sample set, and apply it to a mutational data set in colorectal cancer."
The Intolerance of Regulatory Sequence to Genetic Variation Predicts Gene Dosage Sensitivity Petrovski et al. (2015) in PloS Genetics "Here, we present two approaches intended to help identify noncoding regions of the genome that may carry mutations influencing disease. The first approach is based on comparing observed and predicted levels of standing human variation in the noncoding exome sequence of a gene. The second approach is based on the phylogenetic conservation of a gene’s noncoding exome sequence using GERP++. We find that both approaches can predict genes known to cause disease through changes in expression level, genes depleted of loss-of-function alleles in the general population, and genes permissive of copy number variants in the general population."
Genotype-frequency estimation from high-throughput sequencing data Maruki and Lynch (2015) in Genetics
Alternative splicing QTLs in European and African populations. Ongen and Dermitzakis (2015) in American Journal of Human Genetics
Risk of bias in reports of in vivo research: a focus for improvement Macleod et al. (2015) in PLoS Biology
Paleophysiology: from fossils to the future Vermeij (2015) in Trends in Ecology and Evolution
Ape parasite origins of human malaria virulence genes. Larremore et al. (2015) in Nature Communications